Modeling of the receptor, G-protein and effector reactions in vertebrate olfactory receptor neurons
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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Hundreds of different receptors regulate the activity of effector proteins with the assistance of heterotrimeric guanine nucleotide-binding proteins (G proteins). The hypothesis that G protein-coupled receptors (R) govern their effectors (E) indirectly via a shuttling mechanism involving the exchange of heterotrimeric G proteins (G[alpha betagamma]) or parts thereof (G[alpha], G[betagamma]) bet...
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Considerable progress has been made in the understanding of transduction mechanisms in olfactory receptor neurons (ORNs) over the last decade. Odorants pass through a mucus interface before binding to odorant receptors (ORs). The molecular structure of many ORs is now known. They belong to the large class of G protein-coupled receptors with seven transmembrane domains. Binding of an odorant to ...
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One of the recent controversies in olfaction has been the relative contribution of the cAMP and InsP 3 (IP 3) second messenger pathways in olfactory transduction, especially in vertebrates, and whether individual odor-ants specifically act via the two pathways. This controversy has been profitably addressed in a recent study by Takeuchi et al. (2003, in this issue). Odorants are known to bind t...
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Often assumed to be epiphenomena of a cell's activity, extracellular currents and resulting potential changes are increasingly recognized to influence the function of other cells in the vicinity. Experimental evidence shows that even small electric fields can modulate spike timing in neurons. Moreover, when neurons are brought close together experimentally or in pathological conditions, activit...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2008
ISSN: 1471-2202
DOI: 10.1186/1471-2202-9-s1-o10